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avanti research  (Croda International Plc)

 
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    Croda International Plc avanti research
    Avanti Research, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 90/100, based on 33 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/857123p/16%3A0+Lyso+PA/pmc13015257-20-8-8
    Average 90 stars, based on 33 article reviews
    avanti research - by Bioz Stars, 2026-10
    90/100 stars

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    other:

    Article Title: The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis.
    Article Snippet: LPA 16:0 (857123P), 18:0 (857128P) and 18:1 (857130P) was obtained from Avanti Polar Lipids (Alabaster, AL, USA), LPA 18:2 (L-0182) and 20:4 (L-0204) from Echelon Bioscience (Salt Lake City, UT, USA).

    Article Title: Lipochaperoning folding of water-soluble functional membrane protein in genetically and biosynthetically tuned Escherichia coli
    Article Snippet: 1-palmitoyl-2-hydroxy- sn -glycero-3-phosphate lysophosphatidic acid (16:0 LPA) , Avanti Research , 857123P.

    Article Title: Methods for identifying modulators of GPR92
    Article Snippet: LPA ligands: 14:0 LPA (1-myristoyl-2-hydroxy-sn-glycero-3-phosphate, sodium salt), Avanti Polar Lipids, cat. 857120P; 16:0 LPA (1-palmitoyl-2-hydroxy-sn-glycero-3-phosphate, sodium salt), Avanti Polar Lipids, cat. 857123P; 18:1 LPA (1-oleoyl-2-hydroxy-sn-glycero-3-phosphate, sodium salt), Avanti Polar Lipids, cat. 857130P.

    Article Title: Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages
    Article Snippet: The LPA species 16:0 (857123P), 18:0 (857128P), and 18:1 (857130P) were obtained from Avanti Polar Lipids (Alabaster, AL, USA), 18:2 LPA (L-0182), 20:4 LPA (L-0204) from Echelon Bioscience (Salt Lake City, UT, USA), MCP-1/CCL2 (571402) and M-CSF (BLD-574804) from Biozol (Eching, Germany).



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    RHO/RAC1-signaling-associated phosphosites regulated by <t>LPA</t> <t>species</t> in MDMs. Phosphoproteomic data from for individual proteins and samples. ( A ) Rho signaling associated proteins with upregulated phosphosites by 18:0 LPA (blue) or 20:4 LPA (red) identified by phosphoproteomics (nominal p < 0.05; FC > 1.1). The plot shows the FC for n = 4 biological replicates. ( B ) Plot as in panel ( A ) for proteins with downregulated phosphosites. *** p < 0.001; ** p < 0.01 for AA versus solvent by paired t test. ns, not significant.
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    RHO/RAC1-signaling-associated phosphosites regulated by LPA species in MDMs. Phosphoproteomic data from for individual proteins and samples. ( A ) Rho signaling associated proteins with upregulated phosphosites by 18:0 LPA (blue) or 20:4 LPA (red) identified by phosphoproteomics (nominal p < 0.05; FC > 1.1). The plot shows the FC for n = 4 biological replicates. ( B ) Plot as in panel ( A ) for proteins with downregulated phosphosites. *** p < 0.001; ** p < 0.01 for AA versus solvent by paired t test. ns, not significant.

    Journal: Cells

    Article Title: Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages

    doi: 10.3390/cells13100810

    Figure Lengend Snippet: RHO/RAC1-signaling-associated phosphosites regulated by LPA species in MDMs. Phosphoproteomic data from for individual proteins and samples. ( A ) Rho signaling associated proteins with upregulated phosphosites by 18:0 LPA (blue) or 20:4 LPA (red) identified by phosphoproteomics (nominal p < 0.05; FC > 1.1). The plot shows the FC for n = 4 biological replicates. ( B ) Plot as in panel ( A ) for proteins with downregulated phosphosites. *** p < 0.001; ** p < 0.01 for AA versus solvent by paired t test. ns, not significant.

    Article Snippet: The LPA species 16:0 (857123P), 18:0 (857128P), and 18:1 (857130P) were obtained from Avanti Polar Lipids (Alabaster, AL, USA), 18:2 LPA (L-0182), 20:4 LPA (L-0204) from Echelon Bioscience (Salt Lake City, UT, USA), MCP-1/CCL2 (571402) and M-CSF (BLD-574804) from Biozol (Eching, Germany).

    Techniques: Phospho-proteomics, Solvent

    Comparative phosphoproteomic analysis of MDMs treated with 20:4 LPA versus ascites-emulating LPA mix. MDMs were treated as in . ( A ) Volcano plot of LPA-mix regulated phosphosites. Green: downregulated sites (nominal p < 0.05). Orange: upregulated sites ( p < 0.05). Grey: sites not significantly affected. Horizontal line: significance threshold ( p = 0.05). Numbers: significantly downregulated (green) and upregulated (orange) genes. ( B ) Venn diagram of phosphosites upregulated by LPA mix or 18:0/20:4 LPA species (nominal p < 0.05). ( C ) Venn diagram of phosphosites downregulated by LPA mix or 18:0/20:4 LPA species ( p < 0.05). ( D ) Venn diagram of proteins with phosphosites (in panel ( B )) upregulated by LPA mix or 18:0/20:4 LPA species. ( E ) Venn diagram of proteins with phosphosites (in panel ( B )) downregulated by LPA mix or 18:0/20:4 LPA species. ( F ) Protein kinases with phosphosites up- or downregulated by LPA mix (gray area) or 18:0/20:4 LPA species (pink area). ( G ) Reactome analysis of LPA-mix-regulated protein kinases. The plot shows the most significant (FDR) enriched non-redundant terms.

    Journal: Cells

    Article Title: Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages

    doi: 10.3390/cells13100810

    Figure Lengend Snippet: Comparative phosphoproteomic analysis of MDMs treated with 20:4 LPA versus ascites-emulating LPA mix. MDMs were treated as in . ( A ) Volcano plot of LPA-mix regulated phosphosites. Green: downregulated sites (nominal p < 0.05). Orange: upregulated sites ( p < 0.05). Grey: sites not significantly affected. Horizontal line: significance threshold ( p = 0.05). Numbers: significantly downregulated (green) and upregulated (orange) genes. ( B ) Venn diagram of phosphosites upregulated by LPA mix or 18:0/20:4 LPA species (nominal p < 0.05). ( C ) Venn diagram of phosphosites downregulated by LPA mix or 18:0/20:4 LPA species ( p < 0.05). ( D ) Venn diagram of proteins with phosphosites (in panel ( B )) upregulated by LPA mix or 18:0/20:4 LPA species. ( E ) Venn diagram of proteins with phosphosites (in panel ( B )) downregulated by LPA mix or 18:0/20:4 LPA species. ( F ) Protein kinases with phosphosites up- or downregulated by LPA mix (gray area) or 18:0/20:4 LPA species (pink area). ( G ) Reactome analysis of LPA-mix-regulated protein kinases. The plot shows the most significant (FDR) enriched non-redundant terms.

    Article Snippet: The LPA species 16:0 (857123P), 18:0 (857128P), and 18:1 (857130P) were obtained from Avanti Polar Lipids (Alabaster, AL, USA), 18:2 LPA (L-0182), 20:4 LPA (L-0204) from Echelon Bioscience (Salt Lake City, UT, USA), MCP-1/CCL2 (571402) and M-CSF (BLD-574804) from Biozol (Eching, Germany).

    Techniques:

    Regulation of protein kinase phosphorylation by LPA in MDMs. Serum-deprived MDMs were treated with 5 µM LPA or solvent for 30 min and analyzed by immunoblotting. ( A ) Characteristic immunoblot showing the effect of 18:0 LPA, 20:4 LPA, and LPA mix on MLC2 phosphorylation. MLC was included for normalization of phosphoform signals. ( B ) Quantification of n = 5 biological samples (FC relative to solvent). ( C ) Immunoblot as in panel ( A ) analyzing effects of 18:0 LPA, 20:4 LPA and LPA mix on AKT1 and p38 phosphorylation. ( D ) Quantification of changes in pp38 levels for n = 5 biological replicates for 5 different LPA species. ( E ) Quantification of changes in pAKT1 levels for n = 5 biological replicates. Colored data points represent individual samples, the horizontal line indicates the median. Significance was tested by paired t -test: ** p < 0.01; * p < 0.05, ns, not significant.

    Journal: Cells

    Article Title: Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages

    doi: 10.3390/cells13100810

    Figure Lengend Snippet: Regulation of protein kinase phosphorylation by LPA in MDMs. Serum-deprived MDMs were treated with 5 µM LPA or solvent for 30 min and analyzed by immunoblotting. ( A ) Characteristic immunoblot showing the effect of 18:0 LPA, 20:4 LPA, and LPA mix on MLC2 phosphorylation. MLC was included for normalization of phosphoform signals. ( B ) Quantification of n = 5 biological samples (FC relative to solvent). ( C ) Immunoblot as in panel ( A ) analyzing effects of 18:0 LPA, 20:4 LPA and LPA mix on AKT1 and p38 phosphorylation. ( D ) Quantification of changes in pp38 levels for n = 5 biological replicates for 5 different LPA species. ( E ) Quantification of changes in pAKT1 levels for n = 5 biological replicates. Colored data points represent individual samples, the horizontal line indicates the median. Significance was tested by paired t -test: ** p < 0.01; * p < 0.05, ns, not significant.

    Article Snippet: The LPA species 16:0 (857123P), 18:0 (857128P), and 18:1 (857130P) were obtained from Avanti Polar Lipids (Alabaster, AL, USA), 18:2 LPA (L-0182), 20:4 LPA (L-0204) from Echelon Bioscience (Salt Lake City, UT, USA), MCP-1/CCL2 (571402) and M-CSF (BLD-574804) from Biozol (Eching, Germany).

    Techniques: Phospho-proteomics, Solvent, Western Blot

    Actin cytoskeleton rearrangement in MDMs treated with 18:0 of 20:4 LPA. ( A ) Representative photomicrographs of phalloidin-stained MDMs treated with 5 µM LPA species or solvent for 30 min. Nuclei were counterstained with DAPI. ( B ) Quantification of n = 4–6 biological replicates, 3 random fields were evaluated for each sample. Cells with distinct actin rearrangement (accumulation at the plasma membrane) were counted as positive. Colored data points represent individual samples, the horizontal line indicates the median. Significance was tested by paired t -test: ** p < 0.01; * p < 0.05.

    Journal: Cells

    Article Title: Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages

    doi: 10.3390/cells13100810

    Figure Lengend Snippet: Actin cytoskeleton rearrangement in MDMs treated with 18:0 of 20:4 LPA. ( A ) Representative photomicrographs of phalloidin-stained MDMs treated with 5 µM LPA species or solvent for 30 min. Nuclei were counterstained with DAPI. ( B ) Quantification of n = 4–6 biological replicates, 3 random fields were evaluated for each sample. Cells with distinct actin rearrangement (accumulation at the plasma membrane) were counted as positive. Colored data points represent individual samples, the horizontal line indicates the median. Significance was tested by paired t -test: ** p < 0.01; * p < 0.05.

    Article Snippet: The LPA species 16:0 (857123P), 18:0 (857128P), and 18:1 (857130P) were obtained from Avanti Polar Lipids (Alabaster, AL, USA), 18:2 LPA (L-0182), 20:4 LPA (L-0204) from Echelon Bioscience (Salt Lake City, UT, USA), MCP-1/CCL2 (571402) and M-CSF (BLD-574804) from Biozol (Eching, Germany).

    Techniques: Staining, Solvent, Clinical Proteomics, Membrane

    Transwell migration assay of MDMs treated with 18:0 of 20:4 LPA. ( A ) Crystal-violet-stained after 24 h migration towards a gradient of human serum and MCP-1/CCl-2 (50 ng/mL) in the presence of 5 µM LPA species or solvent. ( B ) Quantification of n = 7 biological replicates, 3 random fields were analyzed for each sample. Colored data points represent individual samples, the horizontal line indicates the median. Significance was tested by paired t -test: ** p < 0.01; * p < 0.05.

    Journal: Cells

    Article Title: Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages

    doi: 10.3390/cells13100810

    Figure Lengend Snippet: Transwell migration assay of MDMs treated with 18:0 of 20:4 LPA. ( A ) Crystal-violet-stained after 24 h migration towards a gradient of human serum and MCP-1/CCl-2 (50 ng/mL) in the presence of 5 µM LPA species or solvent. ( B ) Quantification of n = 7 biological replicates, 3 random fields were analyzed for each sample. Colored data points represent individual samples, the horizontal line indicates the median. Significance was tested by paired t -test: ** p < 0.01; * p < 0.05.

    Article Snippet: The LPA species 16:0 (857123P), 18:0 (857128P), and 18:1 (857130P) were obtained from Avanti Polar Lipids (Alabaster, AL, USA), 18:2 LPA (L-0182), 20:4 LPA (L-0204) from Echelon Bioscience (Salt Lake City, UT, USA), MCP-1/CCL2 (571402) and M-CSF (BLD-574804) from Biozol (Eching, Germany).

    Techniques: Transwell Migration Assay, Staining, Migration, Solvent